THE JOURNEY OF STEM CELLS:
Material-based systems for engineering new vascular networks
Eduardo A. Silva, Ph.D.
Assistant Professor, Biomedical Engineering
University of California, Davis
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Tuesday, November 24th
6:00 - 7:00 pm
University Union, Ballroom Room 1
The Sacramento State STEM Regenerative Medicine Lecture Series welcomes Dr. Eduardo A. Silva, Assistant Professor of Biomedical Engineering at the University of California, Davis. His talk titled “The Journey of Stem Cells: Material-based systems for engineering new vascular networks” will address his current research focused on stem cell-based approaches for treating critical limb ischemia (CLI).
Ischemic vascular diseases remain the leading cause of mortality among elderly American. Peripheral artery disease (PAD) is dangerous because it reduces blood flow to body tissues and vital organs. Current therapies for PAD aim to reduce risk with lifestyle changes, antiplatelet drugs, and statins before intervening surgically with either bypass or endovascular revascularization. However, for those patients who fail to respond to first-line therapies, the manifestations of PAD include critical limb ischemia (CLI). Despite positive results with animal and small-scale clinical studies, large clinical trials of stem cell-based approaches for CLI have not demonstrated a significant effect. Why has there been such poor correlation between animal studies and clinical trials to date? Discussion will cover some of the challenges involving both engineering and biological aspects.
Eduardo A. Silva received his BS in Metallurgical and Materials Science Engineering from University of Porto, Portugal and his PhD in Engineering Sciences: Bioengineering, jointly from University of Porto and Harvard University. His laboratory aims to develop new material-based strategies intended to minimize any manipulations of biological agents outside the Body. Silva is well published and has received the Wyss Technology Development fellowship award.
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