Dr.  Kathie McReynolds

B.S. Biochemistry Cal Poly SLO, 1994
M.A. Chemistry University of Arizona 1996
Ph.D. Chemistry University of Arizona 1999
Postdoc Univ. California, Davis 1999-2001

http://kekule.chem.csus.edu/kmz/indexF05.htm

Chem 6A/6B
Chem 161
Chem 162
Chem 164
Chem 160a/b

My research is focused on the development of novel branched sugar-based polymers, known as glycodendrimers, as potential therapeutic agents.  Much of the current work in the lab is devoted to the synthesis and chemical characterization of the dendrimers and glycodendrimers.  This process involves using several chemical techniques such as TLC, chromatography (flash, size exclusion, ion exchange, HPLC), NMR and interpretation of mass spectral data. 

In addition to these techniques, additional work is currently underway to investigate the biological properties of the glycodendrimers using ELISA (enzyme-linked immunosorbent assay).  Once biologically active compounds have been identified, further testing of the compounds will be conducted and will include cell culture toxicity assays and live pathogen assays. 

McReynolds, K.D.  Glycobiology:  How to Sugar-Coat an Undergraduate Advanced Biochemistry Lab.  Biochem. Mol. Biol. Educ. (Manuscript accepted).

McReynolds, K.D.; Gervay-Hague, J.  Chemotherapeutic Interventions Targeting HIV-Carbohydrate Interactions.  Chem. Rev. (Manuscript submitted).

Presentations

K.D. McReynolds Studies Directed Towards the Synthesis of Novel Glycodendrimers as Potential Therapeutic Agents, Invited talk at the Rocky Mountain Regional American Chemical Society Meeting, October 2006. 

K.D. McReynolds Glycodendrimers as Novel Anti-Viral Agents, Invited seminar at The University of the Pacific, Stockton, CA, November 2005.  (oral presentation)

K.D. McReynolds (no title submitted).  Invited speaker/participant at the NSF Workshop on Physical Organic Chemistry, Bodega Bay, CA, August 2005. (oral presentation) 

K.D. McReynolds The Study of Glycobiology in an Undergraduate Advanced Biochemistry Laboratory.  Presented at the 229th American Chemical Society National Meeting, CHED 258, San Diego, CA, March 2005. (oral presentation) 

K.D. McReynolds  Incorporation of Carbohydrates into an Advanced Biochemistry Laboratory.  Presented at the 39th Annual American Chemical Society Western Regional Meeting, Sacramento, CA, October 27-30th 2004. (oral presentation)

S. Lindgren, Ballard, R., M. McCarthy-Hintz, L. Roberts, N. Ewing, D. Bell, K. McReynolds  Development of a Molecular Biology Interdisciplinary Group at CSU Sacramento. Presented at the 15th Annual CSU Biotechnology Symposium, Pomona, CA, January 2003. (Poster)

Student Presentations (* for undergraduate, ^ for graduate)

D. Glick* and K.D. McReynolds  Synthesis of Dendrimer Cores from Simple Ether-Based Building Blocks. Presented at the 18th CSU Biotechnology Symposium (CSUPERB), San Jose, CA, January 13-14th 2006.  (poster)

M. Creech^ and K.D. McReynolds  Divergent Synthesis of N-Acetylglucosamine Terminated Tertiary Amine Dendrimers. Presented at the 18th CSU Biotechnology Symposium (CSUPERB), San Jose, CA, January 13-14th 2006.  (poster)

R. Clayton^ and K.D. McReynolds  Synthesis of Multivalent Dendrimers Based on a Poly(amidoamine) Core. Presented at the 18th CSU Biotechnology Symposium (CSUPERB), San Jose, CA, January 13-14th 2006.  (poster)

R. Blackeye* and K.D. McReynolds  The Formation of Dendrimers with Ethereal Links.  Presented at the 18th CSU Biotechnology Symposium (CSUPERB), San Jose, CA, January 13-14th 2006.  (poster)

R. Blackeye* and K.D. McReynolds  Ethereal Molecules as Links for Convergent Dendrimer Synthesis.  Presented at the Annual Biomedical Research Conference for Minority Students (ABRCMS), Atlanta, GA, November 2-5th 2005. (poster)

R. Blackeye* and K.D. McReynolds  Synthesis of an Ethereal Tosylate Linker for Convergent Dendrimer Formation.  Presented at the 17th annual American Chemical Society Undergraduate Research Symposium, Oakland, CA, April 30th 2005.  (poster)

P. Chandra* and K.D. McReynolds  Determination and Assessment of Equilibrium Conformations of PAMAM and Ether-based Dendrimers using Computational Methods. Presented at the 17th annual American Chemical Society Undergraduate Research Symposium, Oakland, CA, April 30th 2005.  (poster).

M. Creech* and K.D. McReynolds  Formation of N-Acetylglucosamine-Terminated Tertiary Amine Glycodendrimers. Presented at the 17th annual American Chemical Society Undergraduate Research Symposium, Oakland, CA, April 30th 2005.  (poster). 

D. Glick* and K.D. McReynolds  Progress Toward the Synthesis of 6-Amino-4-Oxahexanoate. Presented at the 17th annual American Chemical Society Undergraduate Research Symposium, Oakland, CA, April 30th 2005.  (poster). 

S. Kouchakali* and K.D. McReynolds  Dendrimer Branching Chemistry to Yield Higher Order Generations. Presented at the 17th annual American Chemical Society Undergraduate Research Symposium, Oakland, CA, April 30th 2005.  (poster).

P. Chandra* and K.D. McReynolds  Determination and Assessment of Equilibrium Conformations of Carbohydrate Dendrimers using Computational Methods.  Presented at the 39th Annual American Chemical Society Western Regional Meeting, Sacramento, CA, October 27-30th 2004. (poster).

S. Burr* and K.D. McReynolds  Sulfation and Purification of Colominic Acid Oligomers.  Presented at the 16th Annual American Chemical Society Undergraduate Research Symposium, Santa Clara, CA, May 8, 2004.  (Poster)

M. Soto* and K.D. McReynolds  Synthesis of Novel Glycodendrimers Without the Use of Protecting Group Chemistry.  Presented at the 15th Annual American Chemical Society Undergraduate Research Symposium, San Francisco, CA, May 2003.  (Poster)

M. Soto* and K.D. McReynolds  Glycodendrimers:  Development of a Weapon Against HIV.  Presented at the 15th Annual CSU Biotechnology Symposium, Pomona, CA, January 2003.  (Poster)

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