Dr.  Katherine McReynolds, Associate Professor

kathie



Education

B.S. Biochemistry Cal Poly SLO, 1994

M.A. Chemistry University of Arizona 1996

Ph.D. Chemistry University of Arizona 1999

Postdoc Univ. California, Davis 1999-2001

Office: SQU 540C

Phone:(916) 278-6551

Email:kdmcr@csus.edu



Home page

Courses

Chem 5 - Chemistry for Nurses
Chem 6A - Introduction to General Chemistry
Chem 6B - Introduction to Organic and Biological Chemistry
Chem 20 - Organic Chemistry Lecture
Chem 24 - Organic Chemistry Lecture I
Chem 161 - General Biochemistry
Chem 162 - Gerneral Biochemistry Laboratory
Chem 164 - Advanced Biochemistry Laboratory
Chem 160A - Structure and Function of Biological Molecules
Chem 160B - Metabolism and Regulation of Biological Systems

Research:

My research is focused on the development of novel branched sugar-based polymers, known as glycodendrimers, as potential therapeutic agents. Much of the current work in the lab is devoted to the synthesis and chemical characterization of the dendrimers and glycodendrimers. This process involves using several chemical techniques such as TLC, chromatography (flash, size exclusion, ion exchange, HPLC), NMR and interpretation of mass spectral data.

In addition to these techniques, additional work is currently underway to investigate the biological properties of the glycodendrimers using ELISA (enzyme-linked immunosorbent assay). Once biologically active compounds have been identified, further testing of the compounds will be conducted and will include cell culture toxicity assays and live pathogen assays.

Recent Publications and Presentations:

Selected Publications:

^Clayton, R.McReynolds, K.D.Synthesis of Sialic Acid-PAMAM Glycodendrimers without the Use of Protecting Groups.Manuscript in preparation.

^Watterson, M.McReynolds, K.D.Synthesis of Novel Glucosamine-Based Glycodendrimers. Manuscript in preparation.

*Patane, J.; *Trapani, V.; *Villavert, J.McReynolds, K.D.Preparative Production of Colominic Acid Oligomers via a Facile Microwave Hydrolysis.Carb. Res.2009,344, 820-824.

McReynolds, K.D.; Gervay-Hague, J. Chemotherapeutic Interventions Targeting HIV Interactions with Host-Associated Carbohydrates.Chem. Rev.,2007,107(5), 1533-1552.

McReynolds, K.D.Glycobiology:  How to Sugar-Coat an Undergraduate Advanced Biochemistry Lab.Biochem. Mol. Biol. Educ. 2006,34(5), 369-377.

Conboy, J.C.McReynolds, K.D.; Gervay-Hague, J.; Saavedra, S.S. Quantitative Measurements of Recombinant HIV Surface Glycoprotein Gp120 Binding to Several Glycosphingolipids Expressed in Planar Supported Lipid Bilayers.J. Am. Chem. Soc.,2002,124(6), 968-977.

McReynolds, K.D.; Bhat, A.; Conboy, J.C.; Saavedra, S.S.; Gervay-Hague, J. Non-natural Glycosphingolipids and Structurally Simpler Analogs Bind HIV-1 Recombinant Gp120.Bioorg. Med. Chem.2002,10(3), 625-637.

Selected Presentations:

K.D. McReynolds; How Sweet It Is: Perspectives on the Importance of Carbohydrates in Biochemistry, Medicine and the Mainstream, Award address for receipt of the CSUS President’s Award for Research and Creative Activity, October 27, 2010.

K.D. McReynolds; Studies Directed Towards the Synthesis of Novel Glycodendrimers as Potential Therapeutic Agents, Invited talk at the Rocky Mountain Regional American Chemical Society Meeting, October 2006.

K.D. McReynolds; Glycodendrimers as Novel Anti-Viral Agents, Invited seminar at The University of the Pacific, Stockton, CA, November 2005.

K.D. McReynolds; (no title submitted).Invited speaker/participant at the NSF Workshop on Physical Organic Chemistry, Bodega Bay, CA, August 2005.

K.D. McReynolds; The Study of Glycobiology in an Undergraduate Advanced Biochemistry Laboratory.Presented at the 229th American Chemical Society National Meeting, CHED 258, San Diego, CA, March 2005.

K.D. McReynolds; Incorporation of Carbohydrates into an Advanced Biochemistry Laboratory.Presented at the 39th Annual American Chemical Society Western Regional Meeting, Sacramento, CA, October 27-30th 2004.

S. Lindgren, Ballard, R., M. McCarthy-Hintz, L. Roberts, N. Ewing, D. Bell,K. McReynoldsDevelopment of a Molecular Biology Interdisciplinary Group at CSU Sacramento. Presented at the 15th Annual CSU Biotechnology Symposium, Pomona, CA, January 2003.

Selected Student Presentations (* for undergraduate, ^ for graduate):

V.J. Trapani*;D. Glick*; and K. McReynoldsb-Lactosyl Amine Glycodendrimer Synthesis by Means of Amide Linkages.Presented at the Presented at the 22nd Annual Northern California Undergraduate Research Symposium, Sacramento, CA, May 2010.

R. Blackeye^;K. McReynoldsCreating Glycodendrimers via Maltose and an Amino Tris Core. Presented at the 239th National American Chemical Society Meeting, San Francisco, CA, March 21-25th 2010, CARB 35.

M.L. Watterson^;K. McReynoldsConvergent Synthesis of Two N-Acetylglucosamine Terminated Dendrimers.Presented at the 239th National American Chemical Society Meeting, San Francisco, CA, March 21-25th 2010, CARB 36 and Sci-Mix.

R.G. Clayton^;K. McReynoldsSynthesis of Multiple Sialic Acid-Terminated Dendrimers with a Poly(amidoamine) Core for the Study of the Effect of Generation and Distance from Sugar to Core on Protein Binding Affinity.Presented at the 239th National American Chemical Society Meeting, San Francisco, CA, March 21-25th 2010, CARB 67.

V.J. Trapani*D. Glick*; and K. McReynoldsb-Lactosyl Amine Glycodendrimer Synthesis by Means of Amide Linkages.Presented at the 239th National American Chemical Society Meeting, San Francisco, CA, March 21-25th 2010, CHED 1189.

J.J. Patane*;K.D. McReynolds Convergent and Divergent Synthesis of Lactonic Acid Glycodendrimers via BOP Coupling.Presented at the 239th National American Chemical Society Meeting, San Francisco, CA, March 21-25th 2010, CHED 1190.

V. Trapani*;D. Glick* and K. McReynoldsLactosamine Glycodendrimer Synthesis by Means of an Amide Linkage.Presented at the 21st Annual Northern California Undergraduate Research Symposium, Moraga, CA, May 2009.

J. Patane*;K. McReynoldsSynthesis of Lactonic Acid Glycodendrimers via BOP Coupling.Presented at the 21st Annual Northern California Undergraduate Research Symposium, Moraga, CA, May 2009.

V.J. Trapani*; J.J. Patane*; J.P. Villavert* and K.D. McReynoldsAcid Hydrolysis of Colominic Acid Under Microwave Hydrolysis.Presented at the 21st CSU Biotechnology Symposium (CSUPERB), Los Angeles, CA, January 16-17th 2009.

R.A. Blackeye^and K.D. McReynoldsThe Formation of a Maltose Decorated Dendrimer.Presented at the 21st CSU Biotechnology Symposium (CSUPERB), Los Angeles, CA, January 16-17th 2009.

M. Watterson^and K.D. McReynoldsDivergent Synthesis of an N-Acetylglucosamine Terminated Dendrimer.Presented at the 236th National American Chemical Society Meeting, Philadelphia, PA, August 17-21st 2008, CARB 46 and Sci-Mix.

R. Blackeye^and K.D. McReynoldsReduction and Hydrolysis of a Hexavalent Core for Glycodendrimer Synthesis.Presented at the 236th National American Chemical Society Meeting, Philadelphia, PA, August 17-21st 2008, CARB 60 and Sci-Mix.

R. Clayton^and K.D. McReynoldsSynthesis of a Sialic Acid-Hydrophilic Linker Conjugate of PAMAM.Presented at the 236th National American Chemical Society Meeting, Philadelphia, PA, August 17-21st 2008, CARB 67.

M. Skidmore*The Synthesis of a Sulfated Cellobiose Glycodendrimer as a Potential Anti-Viral Agent.Presented at the 22nd Annual California State University Student Research Competition, CSU East Bay, Hayward, CA, May 2nd 2008.

M. Skidmore*The Synthesis of a Sulfated Cellobiose Glycodendrimer as a Potential Anti-Viral Agent.Presented at the 22nd Annual Student Research Competition, CSU Sacramento, Sacramento, CA, March 15th 2008.

R. Blackeye*and K.D. McReynoldsThe Creation of Glycodendrimers Using an Ethereal Hexavalent Core.Presented at the 20th CSU Biotechnology Symposium (CSUPERB), Oakland, CA, January 11-13th 2008.

M. J. Skidmore*and K.D. McReynoldsThe Synthesis of a Sulfated Cellobiose Glycodendrimer as a Potential Anti-Viral Agent.Presented at the 20th CSU Biotechnology Symposium (CSUPERB), Oakland, CA, January 11-13th 2008.

Completed Master’s Theses:

Russell Clayton: Synthesis of Multiple Sialic Acid-Terminated Dendrimers with a Poly(amidoamine) Core for the Study of the Effect of Generation and Distance of Sugar to Core on Binding Affinity, defense 11/19/10.

Michelle Watterson: Synthesis of Polar Tertiary Amine Dendrimers Terminated with Glucosamine, defense 11/22/10.