**CHEM 230 – Chemical Separations**

**SYLLABUS**

Instructor: Roy Dixon

Office: 446C

Lecture Meeting: Tuesday 5:30 – 8:00 pm (or 5:30 to 8:15 with 15 min break), Sequoia 316

Tentative Office Hours: Mon 12:00-1:00, Tues. 3:30-4:30, Thurs.4:00-5:00.

Phone Number: 278-6893 email: rdixon@csus.edu

Class Web Page: http://www.csus.edu/indiv/d/dixonr/C230/C230.htm.

Textbook: "Chromatography - Concepts and Contrasts", 2nd Edition by James M. Miller, John Wiley & Sons (2005) Hoboken, NJ.

Additional reading assignments will be given.

**Course
Description:** Chemical Separations
are used in the isolation and/or analysis of chemicals in a variety of media
for solving numerous problems. This course will emphasize the theory and some
basic applications of methods of separations. Types of separations covered
will include simple one-step separations, chromatographic separations, and
other advanced types of separation like electrophoresis. The course will
include detailed theory of separations from partitioning across phases to understanding
what affects separation performance in chromatography. Modern gas
chromatography and high performance liquid chromatography, particularly for
analysis of complex samples will be emphasized. A portion of the course will
emphasize student directed learning/teaching.

**Tentative
Schedule (This may change somewhat):**

Date Main Subject(s) Text Pages

Sept. 2 Introduction / simple separations 1-30; 387-398

Sept. 9 Liquid-liquid extractions 398-412

Sept. 16 Advanced extraction procedures

Sept. 23 Introduction to chromatography I 35-64

**Sept.
23 Exam 1 (Extractions)**

Sept. 30 Theory of chromatographic separations 64-91; 93-101

Oct. 7 Optimization; GC 109-115; 117-124; 141-147

Oct. 14 GC 148-176; 423-427

**Oct.
14 Exam 2 (Chromatographic Theory)**

Oct. 21 SFC, LC 124-134; 183-214

Oct. 28 LC 214-258

Nov. 4 Quantification 277-306

**Nov.
4 Exam 3 (GC/SFC/LC)**

Nov. 11 Holliday (Veteran’s Day)

Nov. 18 Mass Spectrometry 309-326

Nov. 25 MS/Electrophoretic Methods 365-383

Dec. 2 Student Presentations I

**Dec.
2 Exam 4 (Quantification through Electrophersis)**

Dec. 9 Student Presentations II

**Dec.
15 Final Exam 5:15-7:15* (based on F’13 calendar – may change later)**

** **

**Grading:** Grades will be calculated based on the following
criteria: 4 exams (48%), final exam (30%), presentation (8%), applications
paper (6%), homework (8%).

**Exams: **There will be four exams of 40 min each (during the
first 40 min. of class). There are no plans for make-up exams. Missed exams
for legitimate reasons will result in the remaining exams still counting form
48% of the grade. The exams will cover both problem solving methodology and
general knowledge of topics.

**Final Exam: **The final exam will be comprehensive covering all
topics covered by the instructor with greater focus (about 35% of the points)
on the special topics covered in student presentation.

**Presentations: **The core topics will be taught by the instructor.
Students will be sign up to research and present more specialized separation
topics for the last 2 class meetings. There will be a list of topics to choose
from. There will be a couple of specialized separation topics covered by the
instructor and a guest lecturer as examples. Students will work in pairs to
research topics, come up with a set of readings for the class (e.g. journal
review article), example problems, and a presentation describing the topic.
Some time will be reserved for asking questions and for general discussion of
these topics. More specific information is provided on the presentation
handout.

**Applications Paper: **An important part to separations is in its
applications to chemical or related scientific problems. You will be asked to
research a specific research problem of your own choice (e.g. determination of
phenols in wine) in which recent chromatographic improvements are made. You
will write a brief report (4 to 5 pages + figures and references) indicating
why the improvements are useful and providing specific information requested by
the instructor. This is meant to be broader in scope than a homework
assignment but less involved than a term paper.

**Homework:** There will be two types of homework problems. One
type will be for your benefit for practicing for exams. These problems will be
neither collected nor graded. The second type will be collected and graded.
The ones to be collected and graded may be more involved or on topics covered
sooner. Students are welcome to work together on non-collected problems, but
the collected problems should represent their independent work.

** **

**Assignment of grades: **The break-down of grades will depend on the class
average (in other words be curved), but a higher class average will result in
more high grades. The following grading scheme (excluding +’s and –‘s) can be
considered "typical":

A 90 – 100%

B 79 – 90%

C 67 – 79%

D 56 – 67%

** **

**Policy on cheating:** Cheating will not be tolerated. This includes
copying the work of your classmates, using notes during exams (unless allowed),
falsifying data, and plagiarizing others’ work. At a minimum, cheating will
result in a zero grade for that work. Become familiar with CSUS cheating
policies that can be found at: http://www.csus.edu/admbus/umanual/UMA00150.htm.

**Special Needs:** If you have any special needs regarding the class,
or if a legitimate situation comes up during the semester that might interfere
with the class, please let me know as soon as possible, and I will do my best
to accommodate the situation.