Chiral Gas Chromatography – Homework problems

1. List one advantage and one disadvantage of using amino acid derivatives as a chiral stationary phase in GC.

2. What are the three main classes of chiral stationary phases in GC.

3. Explain the disadvantage to the indirect approach in chiral separations using GC.

4. What types of cyclodextrins provide for better enantioselectivities (hint: amino acid application)?