Chiral Gas Chromatography – Homework problems

1. List one advantage and one disadvantage of using amino acid derivatives as a chiral stationary phase in GC.
Advantage: can be used for trace analysis
Disadvantage: derivatization is required

2. What are the three main classes of chiral stationary phases in GC.
⦁    chiral separation on non-racemic chiral amino acid derivatives via hydrogen bonding
⦁    chiral separation on non-racemic chiral metal coordination compounds via complexation
⦁    chiral separation on biogenic cyclodextrin derivatives via inclusion

3. Explain the disadvantage to the indirect approach in chiral separations using GC.
Derivatization is required.

4. What types of cyclodextrins provide for better enantioselectivities (hint: amino acid application)?
Asymmetric cyclodextrins