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Katherine D. McReynolds

Spring 2014

Courses | Education | Honors & Awards | Papers and Publications | Research Projects | Professional Associations

Contact Information

Title: Professor

 

Office Hours:

 

Mondays 3-4:30 PM

E-mail: kdmcr@csus.edu

Office Location:

Office Phone:

SQU 534

(916) 278-6551

Mailing
Address:
Sacramento State
6000 J Street
Sacramento, CA 95819-6057

Course

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Education

  • B.S. Biochemistry, California Polytechnic State University, San Luis Obispo (1994)
  • M.A. Chemistry, The University of Arizona (1996)
  • Ph.D. Chemistry, The University of Arizona (1999); Mentor: Dr. Jacquelyn Gervay-Hague; Dissertation title: 1. Development of a Novel ELISA for the Testing of Glycobioconjugates as Anti-HIV Agents. 2. Synthesis of Potential Inhibitors of the HIV Entry Mechanism. 3. Probing the Secondary Structural Characteristics of Oligosaccharides Utilizing Circular Dichroism.
  • Bank of America/Giannini Foundation Postdoctoral Fellow, University of California, Davis (2000-2001); Mentor: Dr. Frederic A. Troy

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Honors & Awards

  • CSUS Provost's Research Fellow, 2013-2014
  • CSUS President’s Award for Research and Creative Activity, 2010-2011 ( http://www.csus.edu/research/funding/pa/index.htm#recipients )
  • College of Natural Sciences and Mathematics Outstanding Scholarly and Creative Activities Award, 2010-2011
  • T.H. Cheng Outstanding Chemistry Teacher Awardee, CSUS Department of Chemistry, 2001-02
  • Bank of America-Giannini Foundation Postdoctoral Fellowship in Medical Research, 2000-01
  • Carl S. Marvel Fellowship Awardee, The University of Arizona Department of Chemistry, 1998-99
  • Recipient, The University of Arizona Dean’s Fellowship, 1998
  • Mid-Career Fellowship, The University of Arizona Department of Chemistry, 1996

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Papers and Publications (^graduate authors, *undergraduate authors)

  • McReynolds, K.D.; *Dimas, D.; *Le, Hoang A. Synthesis of Hydrophilic Aminooxy Linkers and Multivalent Cores for Chemoselective Aldehyde/Ketone Conjugation. Tetrahedron Lett., submitted.
  • ^Clayton, R.; ^Hardman, J.; LaBranche, C.; McReynolds, K.D. Evaluation of the Synthesis of Sialic Acid-PAMAM Glycodendrimers without the Use of Sugar Protecting Groups, and the Anti-HIV-1 Properties of These Compounds. Bioconj. Chem. 2011, 22, 2186-2197.
  • *Patane, J.; *Trapani, V.; *Villavert, J.; McReynolds, K.D. Preparative Production of Colominic Acid Oligomers via a Facile Microwave Hydrolysis. Carb. Res. 2009, 344, 820-824.
  • McReynolds, K.D.; Gervay-Hague, J. Chemotherapeutic Interventions Targeting HIV Interactions with Host-Associated Carbohydrates. Chem. Rev., 2007, 107(5), 1533-1552.
  • McReynolds, K.D. Glycobiology: How to Sugar-Coat an Undergraduate Advanced Biochemistry Lab. Biochem. Mol. Biol. Educ. 2006, 34(5), 369-377.
  • Conboy, J.C.; McReynolds, K.D.; Gervay-Hague, J.; Saavedra, S.S. Quantitative Measurements of Recombinant HIV Surface Glycoprotein Gp120 Binding to Several Glycosphingolipids Expressed in Planar Supported Lipid Bilayers. J. Am. Chem. Soc., 2002, 124(6), 968-977.
  • McReynolds, K.D.; Bhat, A.; Conboy, J.C.; Saavedra, S.S.; Gervay-Hague, J. Non-natural Glycosphingolipids and Structurally Simpler Analogs Bind HIV-1 Recombinant Gp120. Bioorg. Med. Chem. 2002, 10(3), 625-637.
  • Conboy, J.C.; McReynolds, K.D.; Gervay-Hague, J.; Saavedra, S.S. Gp120 Binds Cooperatively to Several Biologically Relevant Glycosphingolipids: Quantitative Measurements at Equilibrium Using Total Internal Reflection Fluorescence Microscopy. Angew. Chemie Intl. Ed. Engl., 2000, 39(16), 2882-2884.
  • McReynolds, K.D.; Gervay-Hague, J. Examining the Secondary Structures of Unnatural Peptides and Carbohydrate-based Compounds Utilizing Circular Dichroism. Tett. Asymm. 2000, 11(2), 337-362.
  • Gervay, J.; McReynolds, K.D.; Oehrle-Steele, O.; Gregar, T.Q. Chirality studies of carbohydrate-based oligomeric materials: what does circular dichroism mean? Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) 1999, 40(1), 504-505.
  • Gervay, J. and McReynolds, K.D. Utilization of ELISA Technology to Measure Biological Activities of Carbohydrates Relevant in Disease States. Curr. Med. Chem., 1999, 6, 129-153.
  • McReynolds, K.D.; Hadd, M.J.; Gervay-Hague, J. Development of an ELISA for Water Soluble Analytes and Direct Comparison of Gp120 Recognition of GalCer with Related Carbohydrate Ligands. Bioconj. Chem. 1999, 10 (6), 1021-1031.
  • Szabo, L.; Smith, B.L.; McReynolds, K.D.; Parrill, A.L.; Morris, E.R.; Gervay, J. Solid Phase Synthesis and Secondary Structural Studies of (1?5) Amide-Linked Sialooligomers. J. Org. Chem. 1998, 63, 1074-1078.

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Research Projects/Interests

  • Research in the McReynolds group involves the synthesis of unique hydrophilic linkers, dendrimers and glycodendrimers. The glycodendrimers are being developed as potential anti-viral agents. The research involves both traditional and microwave-based synthetic reactions. An additional area of interest for the group involves the development of ELISA-type biological assays to assess the glycodendrimers for anti-viral activity.

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Professional Associations

  • CSUPERB (California State University Program for Education and Research in Biotechnology, http://www.calstate.edu/csuperb/). Member of the Faculty Concensus Group (FCG, 2006-present, Deputy Chair, 2012-present) and Strategic Planning Council (SPC, 2009-present, Deputy Chair, 2012-present)
  • American Chemical Society (1994-present)
  • Phi Kappa Phi (2006- present)
  • Alpha Chi Sigma Professional Chemistry Fraternity (1992-present)

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Last updated: 01/30/2014