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Katherine D. McReynolds

Fall 2021

Courses | Education | Honors & Awards | Papers and Publications | Research Projects | Professional Associations

Contact Information

Title: Professor

 

Office Hours:

 

M: 10-10:50 am, W: 2:30-3:20 pm

E-mail: kdmcr@csus.edu

Office Location:

Office Phone:

SQU 534

(916) 278-6551

Mailing
Address:
Sacramento State
6000 J Street
Sacramento, CA 95819-6057

Courses

  • Chem 160a, Structure and Function of Biological Molecules
  • Chem 6A, Introduction to General Chemistry (Lab)

Education

  • B.S. Biochemistry, California Polytechnic State University, San Luis Obispo (1994)
  • M.A. Chemistry, The University of Arizona (1996)
  • Ph.D. Chemistry, The University of Arizona (1999); Mentor: Dr. Jacquelyn Gervay-Hague; Dissertation title: 1. Development of a Novel ELISA for the Testing of Glycobioconjugates as Anti-HIV Agents. 2. Synthesis of Potential Inhibitors of the HIV Entry Mechanism. 3. Probing the Secondary Structural Characteristics of Oligosaccharides Utilizing Circular Dichroism.
  • Bank of America/Giannini Foundation Postdoctoral Fellow, University of California, Davis (2000-2001); Mentor: Dr. Frederic A. Troy II

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Honors & Awards

  • CSUPERB Andreoli Faculty Service Award, 2021
  • College of Natural Sciences and Mathematics Outstanding University Service Award, 2019-2020
  • CSUS Provost's Research Fellow, 2013-2014
  • CSUS President's Award for Research and Creative Activity, 2010-2011
  • College of Natural Sciences and Mathematics Outstanding Scholarly and Creative Activities Award, 2010-2011
  • T.H. Cheng Outstanding Chemistry Teacher Awardee, CSUS Department of Chemistry, 2001-2002, 2015-2016, 2019-2020
  • Bank of America-Giannini Foundation Postdoctoral Fellowship in Medical Research, 2000-2001
  • Carl S. Marvel Fellowship Awardee, The University of Arizona Department of Chemistry, 1998-1999
  • Recipient, The University of Arizona Dean's Fellowship, 1998
  • Mid-Career Fellowship, The University of Arizona Department of Chemistry, 1996

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Papers and Publications (^graduate authors, *undergraduate authors)

Orcid ID: https://orcid.org/0000-0001-8395-3066

Scopus Author ID: 6602840736

  • *Wells, L.; ^Vierra, C.; ^Hardman, J.; ^Han, Y.; ^Dimas, D.;*Gwarada-Phillips, L.N.; ^Blackeye, R.; Eggers, D.K.; LaBranche, C.C.; Kral, P.; McReynolds, K.D. Sulfoglycodendrimer Therapeutics for HIV-1 and SARS-CoV-2. Advanced Therapeutics 2021, early view. doi:10.1002/adp.202000210 
  • Han, Y.; McReynolds, K.; Kral, P. Retrained Generic Antibodies Can Recognize SARS-CoV-2, J. Phys. Chem. Lett. 2021, 12(5), 1438-1442. doi:10.1021/acs.jpclett.0c03615. PubMed PMID: 33523655; PubMed Central PMCID: PMC7874498.
  • ^Vierra, C.; Eggers, D.K.; LaBranche, C.C.; McReynolds, K.D. An Efficient Microwave-Mediated Synthesis of Hexavalent Sialic Acid Sulfoglycodendrimers as Potential Anti-HIV Agents.   ACS Applied Polymer Materials, 2020, 2 (11), 4345-4351. doi.10.1021/acsapm.0c00538. PubMed PMID: 33681810; PubMed Central PMCID: PMC7929521
  • McReynolds, K.D.; ^Dimas, D.; ^Floyd, G.; *Zeman, K. Development of a Microwave-Assisted Chemoselective Synthesis of Oxime-Linked Sugar Linkers and Trivalent Glycoclusters. Pharmaceuticals, 2019, 12(1), 39. doi:10.3390/ph12010039. PubMed PMID: 30875805; PubMed Central PMCID: PMC6469176.
  • McReynolds, K.D.; *Dimas, D.; *Le, Hoang A. Synthesis of Hydrophilic Aminooxy Linkers and Multivalent Cores for Chemoselective Aldehyde/Ketone Conjugation. Tetrahedron Lett., 2014, 55, 2270-2273. doi:10.1016/j.tetlet.2014.02.085. PubMed PMID: 25382876; PubMed Central PMCID: PMC4220302.
  • ^Clayton, R.; ^Hardman, J.; LaBranche, C.; McReynolds, K.D. Evaluation of the Synthesis of Sialic Acid-PAMAM Glycodendrimers without the Use of Sugar Protecting Groups, and the Anti-HIV-1 Properties of These Compounds. Bioconjugate Chem. 2011, 22, 2186-2197. doi:10.1021/bc200331v. PubMed PMID: 21859137; PubMed Central PMCID: PMC3241508.
  • *Patane, J.; *Trapani, V.; *Villavert, J.; McReynolds, K.D. Preparative Production of Colominic Acid Oligomers via a Facile Microwave Hydrolysis. Carb. Res. 2009, 344, 820-824. doi: 10.1016/j.carres.2009.01.013.PubMed PMID: 19281967; PubMed Central PMCID: PMC2667875.
  • McReynolds, K.D.; Gervay-Hague, J. Chemotherapeutic Interventions Targeting HIV Interactions with Host-Associated Carbohydrates. Chem. Rev., 2007, 107(5), 1533-1552. doi: 10.1021/cr0502652. PubMed PMID: 17439183.
  • McReynolds, K.D. Glycobiology: How to Sugar-Coat an Undergraduate Advanced Biochemistry Lab. Biochem. Mol. Biol. Educ. 2006, 34(5), 369-377. doi: 10.1002/bmb.2006.494034052655. PubMed PMID: 21638721.
  • Conboy, J.C.; McReynolds, K.D.; Gervay-Hague, J.; Saavedra, S.S. Quantitative Measurements of Recombinant HIV Surface Glycoprotein Gp120 Binding to Several Glycosphingolipids Expressed in Planar Supported Lipid Bilayers. J. Am. Chem. Soc., 2002, 124(6), 968-977. doi: 10.1021/ja011225s. PubMed PMID: 11829604.
  • McReynolds, K.D.; Bhat, A.; Conboy, J.C.; Saavedra, S.S.; Gervay-Hague, J. Non-natural Glycosphingolipids and Structurally Simpler Analogs Bind HIV-1 Recombinant Gp120. Bioorg. Med. Chem. 2002, 10(3), 625-637. doi: 10.1016/s0968-0896(01)00325-x. PubMed PMID: 11814851.
  • Conboy, J.C.; McReynolds, K.D.; Gervay-Hague, J.; Saavedra, S.S. Gp120 Binds Cooperatively to Several Biologically Relevant Glycosphingolipids: Quantitative Measurements at Equilibrium Using Total Internal Reflection Fluorescence Microscopy. Angew. Chemie Intl. Ed. Engl., 2000, 39(16), 2882-2884. doi: 10.1002/1521-3773(20000818)39:16<2882::aid-anie2882>3.0.co;2-m. PubMed PMID: 11027997.
  • McReynolds, K.D.; Gervay-Hague, J. Examining the Secondary Structures of Unnatural Peptides and Carbohydrate-based Compounds Utilizing Circular Dichroism. Tett. Asymm. 2000, 11(2), 337-362. doi: 10.1016/S0957-4166(99)00560-1.
  • Gervay, J.; McReynolds, K.D.; Oehrle-Steele, O.; Gregar, T.Q. Chirality studies of carbohydrate-based oligomeric materials: what does circular dichroism mean? Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) 1999, 40(1), 504-505. 
  • Gervay, J. and McReynolds, K.D. Utilization of ELISA Technology to Measure Biological Activities of Carbohydrates Relevant in Disease States. Curr. Med. Chem., 1999, 6, 129-153. PubMed PMID: 10189228.
  • McReynolds, K.D.; Hadd, M.J.; Gervay-Hague, J. Development of an ELISA for Water Soluble Analytes and Direct Comparison of Gp120 Recognition of GalCer with Related Carbohydrate Ligands. Bioconjugate Chem. 1999, 10 (6), 1021-1031. doi: 10.1021/bc990050x. PubMed PMID: 10563771.
  • Szabo, L.; Smith, B.L.; McReynolds, K.D.; Parrill, A.L.; Morris, E.R.; Gervay, J. Solid Phase Synthesis and Secondary Structural Studies of (1?5) Amide-Linked Sialooligomers. J. Org. Chem. 1998, 63, 1074-1078. doi:10.1021/jo971415e.

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Research Projects/Interests

  • Research in the McReynolds group involves the synthesis of unique hydrophilic linkers, dendrimers and glycodendrimers. The glycodendrimers are being developed as potential anti-viral agents. The research involves both traditional and microwave-based synthetic reactions. An additional area of interest for the group involves the development of ELISA-type biological assays to assess the glycodendrimers for anti-viral activity.

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Professional Associations

  • CSUPERB (California State University Program for Education and Research in Biotechnology, http://www.calstate.edu/csuperb/). Member of the Faculty Concensus Group (FCG: 2006-present, Deputy Chair: 2012-18, Chair: 2018-present) and Strategic Planning Council (SPC: 2009-present, Deputy Chair: 2012-18, Chair: 2018-present)
  • American Chemical Society (1994-present)
  • Phi Kappa Phi (2006- present)
  • Alpha Chi Sigma Professional Chemistry Fraternity (1992-present)

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Last updated: 07/28/2021