Name: Johannes Bauer
Title: Assistant Professor
Office Location: Sequoia Hall 524
Office Phone: 916.278.4635
Mailing Address: 6000 J Street, Sacramento, CA 95819
Office Hours: please contact me
Postdoctoral Research Associate, Brown University, Providence, RI
Postdoctoral Fellow, University of Connecticut Health Center, Farmington, CT
Dr. rer. nat. (Ph.D.), Biochemistry, Free University Berlin, Germany
Lectures and Lab courses
Chem 161: General Biochemistry
Chem 162: General Biochemistry Lab
Chem 251: Biochemistry of Aging
My primary research interest is to understand the molecular basis of the aging process, especially with respect to the biochemistry of metabolism and behavior. We use the fruit fly Drosophila melanogaster as our preferred animal model. Drosophila has been used for more than 100 years in research and thus represents the oldest animal model of the modern research era. Work in fruit flies was instrumental in elucidating the principles of modern genetics and developmental biology.
Interestingly, evidence suggests that social behaviors, such as sociability, may be able to influence aging and longevity. Therefore, it may be possible to directly intervene in signaling pathways that modulate social behaviors and thus alter animal life span. In Drosophila, parameters for mating, such as attractiveness or receptivity, are communicated between flies through cuticular hydrocarbons (CH). These CH also function in other contexts, such as social recognition and group behavior. CH pheromones are produced by specialized cells called oenocytes and displayed on the cuticle of the animal in a sex specific manner. During courting, fighting, or other encounters, flies exchange CH, thus communicating important social information.
Our results show that altering fly social environment is sufficient to change fruit fly longevity. In addition, our data further demonstrate that oenocyte-specific reduction of pheromone biosynthetic activity is sufficient to dramatically alter fly pheromone abundance and longevity. These data suggest that social environment is a contributing factor in the determination of aging and longevity. They also hint at possible molecular mechanisms for those effects through the modulation of pheromone biosynthesis.
We are currently investigating this connection between social environment and longevity, using a variety of experimental approaches, from biochemistry and molecular biology to behaviral biology and genetics.
If you are interested in working in Drosophila aging research, please email me or stop by the lab. We are always looking for motivated graduate and undergraduate researchers.
Brown, S.G., Brenman-Suttner, D.B., McInnes, A.G. §, Lew, K. , Moehring, A.J., Bauer, J.H., and Simon, A.F. (2021) Inheritance of pheromone profiles from aged D. melanogaster.
micropublication BIOLOGY, micropub.biology.000459
Thompson, J. B., Su, O. O. §, Yang, N. §, and Bauer, J. H. (2020) Sleep-length differences are associated with altered longevity in the fruit fly Drosophila melanogaster.
Biology Open 9, bio054361
Joseph, N. M, Elphick,N. Y. , Mohammad, S. and Bauer, J.H. (2018) Altered pheromone biosynthesis is associated with sex-specific changes in life span and behavior in Drosophila melanogaster.
Mech Ageing Dev 176, 1-8
Cao, J., Lopez, R., Thacker, J., Moon, J., Jiang, C., Morris, S.N.S., Bauer, J.H., Tao, P., Mason, R. and Lippert, A. (2015) Chemiluminescent Probes for Imaging H2S in Living Animals.
Chem. Sci. 6(3): 1997-85. PMID: 25709805
Bruemmer, K. J., Merrikhihaghi, S., Lollar, C. T., Morris, S. N. S., Bauer, J. H. and Lippert, A. R. (2014) 19F Magnetic Resonance Probes for Live-Cell Detection of Peroxynitrite Using an Oxidative Decarbonylation Reaction.
Chem. Commun. 50(82): 12311-4. PMID: 25180249
Chhabra, R. §, Kolli, S., and Bauer, J.H. (2013) Organically grown food provides health benefits to Drosophila melanogaster.
PLoS ONE, 8(1):e52988. PMCID: 3541339.
Chamseddin, K. §, Khan, S.Q., Nguyen, M.L.H. §, Antosh, M., Morris, S.N., Kolli, S., Neretti, N., Helfand, S.L. and Bauer, J.H. (2012) takeout-dependent longevity is associated with altered Juvenile Hormone signaling.
Mech Ageing Dev 133(11-12): 637-46. PMCID: 3518612.
Morris, S., Coogan, C. §, Chamseddin, K. §, Fernandez-Kim, S.O., Kolli, S., Keller, J.N., and Bauer, J.H. (2012). Development of diet-induced insulin resistance in adult Drosophila melanogaster.
Biochim Biophys Acta-Molecular Basis of Disease, 1822: 1230-1237.
Antosh M, Whitaker R, Kroll A, Hosier S, Chang C, Bauer J, Cooper L, Neretti N, Helfand SL (2011) Comparative transcriptional pathway bioinformatic analysis of Dietary Restriction, Sir2, p53 and resveratrol life span extension in Drosophila.
Cell Cycle 10(6): 904-11; PMID: 21325893
Bauer JH*, Antosh M*, Chang C, Schorl C, Kolli S, Neretti N, Helfand SL (2010) Comparative transcriptional profiling identifies takeout as a gene that regulates life span.
Aging 2(5): 298-310; PMID: 20519778
Bauer JH, Chang C, Bae G§, Morris SN§, Helfand SL (2010) Dominant-negative Dmp53 extends life span through the dTOR pathway in D. melanogaster.
Mech Ageing Dev 131(3): 193-201; NIHMS 20117129
Bauer JH, Helfand SL (2009) Sir2 and longevity: the p53 connection.
Cell Cycle 8(12): 1821; NIHMS 19471127
Bauer JH, Morris SN§, Chang C, Flatt T, Wood JG, Helfand SL (2009) dSir2 and Dmp53 interact to mediate aspects of CR-dependent life span extension in D. melanogaster.
Aging 1(1): 38-48; NIHMS 19851477
Bauer JH, Chang C, Morris SN§, Hozier S, Andersen S§, Waitzman JS§, Helfand SL (2007) Expression of dominant-negative Dmp53 in the adult fly brain inhibits insulin signaling.
Proc Natl Acad Sci U S A 104(33): 13355-13360; NIHMS 17686972
Bauer JH, Helfand SL (2006a) New tricks of an old molecule: lifespan regulation by p53.
Aging Cell 5(5): 437-440; NIHMS 16968311
Bauer JH, Helfand SL (2006b) The humble fly: what a model system can reveal about the human biology of aging.
Med Health R I 89(9): 314-315; NIHMS 17036696
Bauer JH, Poon PC, Glatt-Deeley H, Abrams JM, Helfand SL (2005) Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span.
Curr Biol 15(22): 2063-2068; NIHMS 16303568
Bauer JH, Goupil S, Garber GB, Helfand SL (2004) An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster.
Proc Natl Acad Sci U S A 101(35): 12980-12985; NIHMS 15328413
Wang X, Bauer JH, Li Y, Shao Z, Zetoune FS, Cattaneo E, Vincenz C (2001) Characterization of a p75(NTR) apoptotic signaling pathway using a novel cellular model.
J Biol Chem 276(36): 33812-33820.; PMID: 11451944
Rigamonti D*, Bauer JH*, De-Fraja C, Conti L, Sipione S, Sciorati C, Clementi E, Hackam A, Hayden MR, Li Y, Cooper JK, Ross CA, Govoni S, Vincenz C, Cattaneo E (2000) Wild-type huntingtin protects from apoptosis upstream of caspase-3.
J Neurosci 20(10): 3705-3713.; PMID: 10804212
Bauer JH, Liu KD, You Y, Lai SY, Goldsmith MA (1998) Heteromerization of the gammac chain with the interleukin-9 receptor alpha subunit leads to STAT activation and prevention of apoptosis.
Journal of Biol Chem 273(15): 9255-9260; PMID: 9535918
Pan G, Bauer JH, Haridas V, Wang S, Liu D, Yu G, Vincenz C, Aggarwal BB, Ni J, Dixit VM (1998) Identification and functional characterization of DR6, a novel death domain-containing TNF receptor.
FEBS Lett 431(3): 351-356; PMID: 9714541
§ indicates undergraduate student authors
* indicates shared 1st authorship
Bauer JH, Helfand SL. The Genetics of Dietary Modulation of Lifespan.
Life History Evolution: The Genetics and Physiology of Life History Traits and Trade-Offs (Oxford University Press). (2011)
Helfand SL, Bauer JH, Wood JG. Calorie Restriction in Lower Organisms.
Molecular Biology of Aging (Cold Spring Harbor Laboratory Press). (2008): 73-94.