Publications

Herrmann, J.A., A. Koprowska, T.J. Winters, N. Villanueva, V.D. Nikityuk, F. Pek, E.M. Reis, C.Z. Dominguez, D. Davis, E. McPherson, S.R. Rocco, C. Recendez, S.M. Difuntorum, K. Faeth, M.D. Lopez, H.M. Awwad, R.A. Ghobashy, L. Cappiello, E.L. Neidle, S. Quiñones-Soto, A. B. Reams, 2023. “Gene amplification mutations originate prior to selective stress in Acinetobacter baylyi” G3: Genes, Genetics, and Genomes, 13(3), jkac327. https://doi.org/10.1093/g3journal/jkac327

Reams, A.B. & Roth, J.R., 2015. Mechanisms of gene duplication and amplification In "DNA Recombination". Editors: Stephen Kowalczykowski, Neil Hunter, and Wolf Heyer, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. https://cshperspectives.cshlp.org/content/7/2/a016592.full.pdf

Reams, A. B. E. Kofoid, N. Duleba, and J. R. Roth, 2014.  “Recombination and annealing pathways compete for substrates in making rrn duplications in Salmonella enterica” Genetics, 196:119-135. https://doi.org/10.1534/genetics.113.158519

Quiñones-Soto S., A. B. Reams, and J.R. Roth, 2012.  “Pathways of genetic adaptation: Multi-step origin of mutants under selection without induced mutagenesis in Salmonella enterica” Genetics, 192:987-999. https://doi.org/10.1534/genetics.112.142158

Reams, A. B. E. Kofoid, E. Kugelberg, and J. R. Roth, 2012.  “Formation of duplications by multiple pathways with and without recombination (RecA)” Genetics, 192:397-415. https://doi.org/10.1534/genetics.112.142570

Reams, A. B., E. Kofoid, M. Savageau, and J. R. Roth, 2010.  “Duplication frequency in a population rapidly approaches steady state with or without recombination” Genetics, 184:1077-1094. https://doi.org/10.1534/genetics.109.111963

Roth, J. R., E. Kugelberg, A. B. Reams, and D.I. Andersson, 2006.  “Origins of mutations under selection - the adaptive mutation controversy” Annual Reviews of Microbiology, 13(60), 477-501. https://doi.org/10.1146/annurev.micro.60.080805.142045

Kugelberg E., E. Kofoid, A. B. Reams, D. I. Andersson, and J. R. Roth, 2006.  “Multiple pathways of selected gene amplification during adaptive mutation” PNAS, 2006 Nov 14;103(46):17319-24. https://doi.org/10.1073/pnas.0608309103

Reams, A. B. and E. L. Neidle, 2004. “Selection for gene clustering by tandem duplication” Annual Reviews of Microbiology, 58, 119-142. https://doi.org/10.1146/annurev.micro.58.030603.123806

Reams, A. B. and E. L. Neidle, 2004.  “Gene amplification involves site-specific short homology-independent illegitimate recombination in Acinetobacter sp. strain ADP1” Journal of Molecular Biology, 338(4), 643-56. https://doi.org/10.1016/j.jmb.2004.03.031

Reams, A. B. and E. L. Neidle, 2003.  “Genome plasticity in Acinetobacter: new degradative capabilities acquired by the spontaneous amplification of large chromosomal segments” Molecular Microbiology, 47(5), 1291-1304. https://doi.org/10.1046/j.1365-2958.2003.03342.x

Brzostowicz, P. C., A. B. Reams, T. J. Clark, and E. L. Neidle, 2003.  “Transcriptional cross-regulation of the catechol and protocatechuate branches of the b-ketoadipate pathway contributes to carbon-source dependent expression of the Acinetobacter sp. strain ADP1 pobA gene” Applied and Environmental Microbiology, 69(3), 1598-1606. https://doi.org/10.1128/AEM.69.3.1598-1606.2003

Alternative Links to Publications

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Research Projects/Interests

Our lab focuses on understanding the molecular mechanisms of mutations called gene amplifications and copy number variations (CNVs). Many important biological phenomena, including cancer, infectious diseases, and bioremediation, depend on these mutations to evolve rapidly to their changing environments. Still, the underlying molecular mechanisms remain unclear for all organisms. Our lab aims to unravel these central mysteries along with developing various CNV-related applications, such as discovering new genomic biomarkers for early cancer development and treatment.

To study gene amplifications and copy number variations, our lab utilizes some of the most genetically tractable organisms: bacteria such as E. coli, Salmonella, and Acinetobacter baylyi. The projects are accessible to undergraduate and Master’s students. Students are trained in important multidisciplinary areas that bridge classical and modern genetics with microbiology, molecular biology, experimental evolution, statistics, and computation.

If you are a highly motivated undergraduate student at CSUS or interested in a Master's degree and would like to discuss research opportunities in the D.Reams lab, please email Dr. Reams at andrew.reams@csus.edu.​ For undergraduate students seeking research experience, please see Dr. Reams' teaching webpage for information on the BIO 180 course ​needed before joining our research lab.

Professional Associations

American Society for Microbiology (ASM)

American Association for the Advancement of Science (AAAS)

Advancing Chicanos/Hispanics & Native Americans in Science (SACNAS)

Genetic Society of America (GSA)

Academic Programs

Science Educational Equity Program