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Faculty Research
All sub-disciplines of chemistry are represented by the exciting research being carried out by faculty at Sac State's department of chemistry.
Students can work with faculty on projects relating to the development of new and novel pharmaceuticals, understanding natural and human disturbed processes occurring in our environment, elucidating important biochemical pathways, chemical instrumentation development, novel compound syntheses, computational chemistry, and chemical education, to name a few. Opportunities exist to carry out interdisciplinary research with researchers in other departments as well as with other universities and outside agencies. Many of our faculty have been awarded research grants from external funding agencies to support their work. The department is well equipped to carry out research with modern instrumentation that is available for student use. Most importantly, students get to work alongside their research advisors and learn in an ideal collaborative atmosphere.
The following is an alphabetical list of faculty in the chemistry department who are involved in research with graduate students. A short description of research interests is given. Please contact the individual faculty member for more information, or see their individual websites if available.
Chemistry Faculty Research
| Faculty Member | Research Interest | Office/Lab |
|---|---|---|
| Johannes Bauer Website | Email |
Professor Bauer is interested in the genetics and biochemistry of the aging process using the fruit fly Drosophila melanogaster as a model system. Many current models of the aging process focus on the role molecular damage caused by normal cellular metabolism. The Bauer lab is investigating the influence of extrinsic, or environmental, factors on metabolic homeostasis, molecular damage and gene expression. In particular, the lab has shown that changing the activity of enzymes involved in fatty acid metabolism is sufficient to alter fly behavior and longevity. These findings suggest a link between life span and behavior. | Office: SQU 550C Research Space: SQU 518 |
| Susan Crawford Website | Email |
Professor Crawford's research is focused upon utilizing solid state NMR, X-ray diffraction, and IR spectroscopy to formulate an understanding of structure-function relationships and diffusion processes in porous materials and geologic systems. Development and testing of environmental remediation materials. | Office: TSC 2019 Research Space: TSC 2035 |
| Roy Dixon Website | Email |
Professor Dixon is an analytical chemist interested in development of high performance liquid chromatography detectors and analysis methods. He also is working to use such methods to detect organic compound present in atmospheric particulate matter in lipids used in biodiesel and in glycan profiling. | Office: SQU 508 Research Space: TSC 2025 |
| Benjamin Gherman Website | Email |
Professor Gherman’s research focuses on the computational modeling of bioinorganic chemistry. The principal goal of his research involves the application of computational chemistry methods to study the catalytic chemistry of metalloenzymes and related biomimetic systems. Professor Gherman also maintains several collaborations, for example with Professor Spence using computational methods to study cyclization reactions of enediynes and with Professor Miranda using computational methods to study the electrochemistry of and reactions catalyzed by metal-salens. | Office: TSC 2009 Research Space: TSC 2016 |
| Monica Gonzalez | Numerous neurodegenerative diseases have been linked to the use of pesticides. The Gonzalez lab employs an array of techniques such as cell culture, fluorescent sensors, and microscopy to investigate the effects of pesticides on the morphology and biochemical processes of neurons. The results of these studies will lead to designs of safer alternatives. | Office: SQU 538B |
| Jacqueline Houston Website | Email |
Professor Houston’s research involves studying reaction rates and mechanistic pathways of ligand substitution at oxo-centered transition metal clusters and polyoxometallate anions using NMR. Understanding the kinetics of ligand substitution at metal-oxo clusters has applications in catalysis and materials as well as geoscience. | Office: TSC 2021 Research Space: TSC 2027 |
| Cynthia Kellen-Yuen Website | Email |
Professor Kellen-Yuen is interested in the area of heterocyclic synthesis, particularly in the area of fused rings systems containing multiple Nitrogen atoms. In addition, she is also interested in Green Chemistry, particularly in the area of microwave-assisted organic transformations. She often combines these interests in the creation of new, greener laboratory experiments for use in the teaching laboratories. | Office: TSC 2013 Research Space: TSC 2014 |
| Yujuan Liu Website | Email |
Professor Liu is a chemistry education and material science chemist focused on the development and evaluation of research-based green chemistry experiments for teaching laboratories with modern analytical instrumentation, such as FT-IR, XRD, fluorescence, NMR, SEM, et al. In addition, she is also interessted in assessment of student learning and affect (e.g. motivation, self-efficacy etc.) in lecture and laboratory environments. | Office: SQU 526 Research Space: SQU 514 |
| Claudia Lucero Website | Email |
Professor Lucero’s research focuses on the development of novel strategies that allow for reactions to run in tandem without the need to purify at each step. An attractive feature to tandem strategies is the use of the same catalyst to mediate two sequential reactions. The goal is to construct enantiomerically pure molecules, in an expeditious and efficient manner, and to employ these building blocks for the syntheses of biologically active agents. The research will also focus on studying the mechanisms of the reactions to explain results. | Office: TSC 2017 Research Space: TSC 2014 |
| Katherine McReynolds Website | Email |
Professor McReynolds’ research interests involve the development of new delivery vehicles and targeting strategies of known inhibitors of HIV. The goal of these projects is to increase the selectivity of a drug for the virus-infected cells, and also to improve the antiviral action of moderately active compounds. | Office: SQU 534 Research Space: SQU 512 |
| Justin Miller-Schulze Website | Email |
Professor Miller-Schulze is an Analytical and Environmental Chemist focused on the development and/or adaption of analytical methodology to quantify chemical tracers in environmental or biological matrices. These tracer chemicals are typically small organic molecule tracers that are indicative of a specific activity (for example, caffeine in a river as a tracer of human wastewater). Environmental and biological concentrations of these tracers are usually very low (parts-per-trillion), so quantification involves sensitive techniques such as mass spectrometry preceded by gas or liquid chromatography. | Office: TSC 2011 Research Space: TSC 2025 |
| James Miranda Website | Email |
Professor Miranda’s research interest primarily lies in developing new methodology for the organic synthesis of biologically active molecules. Usually these complex molecules are not only important in medicinal chemistry as therapeutic agents, but are also interesting from a structural point of view. We also seek to understand the mechanism of these important new reactions. A typical researcher in my group can expect to gain experience in a great variety of organic chemistry laboratory techniques as well as gain valuable experience in the common spectroscopic methods available to the organic chemist (NMR, IR, GC/MS, HPLC, cyclic voltammetry, etc...) | Office: TSC 2015 Research Space: TSC 2014 |
| Stefan Paula Website | Professor Paula’s research interests are in the area of computer-assisted drug discovery. My group uses a combination of experimental and computational methodologies to gain an understanding of how small bioactive molecules interact with their protein receptors. The ultimate goal is the design of novel molecules with improved bioactivities. Several enzymes are currently targeted, including calcium ATPases, the sodium/potassium ATPase, xanthine oxidase, the aryl hydrocarbon receptor, and dynamin. | Office: TSC 2007 Research Space: TSC 2018 |
| Rebecca Peebles | Professor Peebles’s research focuses on using high resolution spectroscopy and theoretical methods to understand noncovalent interactions such as hydrogen bonding, and how they affect other molecular processes (like solvation, dissolution, drug function, and material properties). Current projects include: (1) spectroscopically modeling the early stages of solute dissolution in supercritical carbon dioxide (sc-CO2), a novel green solvent, (2) determining precise structures of small organic molecules, with a focus on the effects of substituting fluorine atoms for hydrogen atoms, (3) utilizing data-analytics and related approaches to simplify molecular spectra and identify individual components of chemical mixtures. | Office: SQU 538A Resaerch Space: SQU 520D and SQU Basement Rm. 11 |
| Linda Roberts Website | Email |
Professor Roberts and her students are engaged in studying the structure and lipid-binding properties of apolipoprotein A-I, the major protein in HDL (the “good” cholesterol). ApoA-I, which has cardioprotective anti-inflammatory and anti-oxidant properties, is correlated with a lowered risk for cardiovascular disease. Yet ApoA-I also has the ability to form amyloid, a type of structure found in many diseases such as Alzheimer’s and Parkinsons. In the case of ApoA-I, the outcome of amyloid structure is increased cardiovascular disease and the development of systemic amyloidoses. In an effort to understand the pathway leading to amyloid formation, our lab focuses on the conditions causing structural changes in ApoA-I and the mechanisms underlying these changes. | Office: SQU 548C Research Space: SQU 548A |
| Thomas Savage Website | Email |
Professor Savage’s research focuses on understanding the regulatory mechanisms controlling the biosynthesis of commercially-important plant products. | Office: SQU 510 Research Space: SQU 512 |
| John Spence Website | Email |
Professor Spence investigates the synthetic organic chemistry of macrocycles related to porphyrins and calixarenes and their potential to fight cancer. | Office: SQU 528 Research Space: SQU 538B |